Dr. Ryan Altman, Purdue University
Area of research: Organic Chemistry/Medicinal Chemistry (Medicinal and Biological Chemistry) write about him.
Introduce the Chemist and his/her research contributions you have decided to highlight. Who are they? What is their background/area of Chemistry? What Department/academic institution?
Identify the specific research or research area you will focus on
What is the main idea of the research? What methods were used in the research? (This would be a good place to cite a review article written by the chemist you are highlighting on the research topic)
Provide examples (at least 3) of this research reported in the literature through research articles or communications. Describe the major findings and cite appropriately with citation numbers in the text.
Explain the novelty and significance of the work. How has this work impacted the field of chemistry?
Describe at least two examples found in the literature (with appropriate citations) where the chemist’s work has inspired or is in some way related to contemporary research.
At least one figure (with figure caption) should be included that illustrates the research topic.
References (Use JACS format): Include at least 7 references: a minimum of 5 peer-reviewed original research articles, plus 2 or more review articles or books.
References:
=> Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan
-Kynurenine Pathway
Yang, Y.; Borel, T.; de Azambuja, F.; Johnson, D.; Sorrentino, J. P.; Udokwu, C.; Davis, I.; Liu, A.;* Altman, R. A.*
J. Med. Chem. 2021, 64, 797–811.
Medicinal Chemistry, Fluorination in Medicinal Chemistry, Kynurenine Pathway
=> Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues
Sorrentino, J. S.; Ambler, B. R.; Altman, R. A.*
J. Org. Chem. 2020, 85, 5416–5427.
Medicinal Chemistry, Fluorination in Medicinal Chemistry
=>Tyr1-ψ[(Z)CFâ•CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin
Altman, R. A.;* Sharma, K. K.; Rajewski, L. G.; Toren, P. C.; Baltezor, M. J.; Pal, M.; Karad, S. N.
ACS Chem. Neurosci. 2018, 9, 1735–1742.
Medicinal Chemistry, Fluorination in Medicinal Chemistry
Use this References:
=> Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan
-Kynurenine Pathway
Yang, Y.; Borel, T.; de Azambuja, F.; Johnson, D.; Sorrentino, J. P.; Udokwu, C.; Davis, I.; Liu, A.;* Altman, R. A.*
J. Med. Chem. 2021, 64, 797–811.
Medicinal Chemistry, Fluorination in Medicinal Chemistry, Kynurenine Pathway
=> Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues
Sorrentino, J. S.; Ambler, B. R.; Altman, R. A.*
J. Org. Chem. 2020, 85, 5416–5427.
Medicinal Chemistry, Fluorination in Medicinal Chemistry
=>Tyr1-ψ[(Z)CFâ•CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin
Altman, R. A.;* Sharma, K. K.; Rajewski, L. G.; Toren, P. C.; Baltezor, M. J.; Pal, M.; Karad, S. N.
ACS Chem. Neurosci. 2018, 9, 1735–1742.
Medicinal Chemistry, Fluorination in Medicinal Chemistry