Categories
Pathophysiology

“Unraveling Inheritance: Understanding the Pathology and Signs of Cystic Fibrosis”

This week, you will have the opportunity to unleash your creativity in order to help you and your classmates study.  
Follow the instructions below and create an infographic or video presentation:
1. Choose a disease that is the result of one of the following: 
Chromosome Aberration (could be polyploidy, aneuploidy, abnormalities of chromosome structures) 
Autosomal Dominant Inheritance 
Autosomal Recessive Inheritance 
X-Linked Inheritance 
Multifactorial Inheritance
2. Briefly explain the major signs and symptoms of the disease, the underlying pathology for the disease, and explain the mode of inheritance for the disorder. Keep in mind that your presentation, video, or infographic should be created to teach your fellow learners about the topic. 
3. Please create these items using infographics (Canva.comLinks to an external site.) or video (Powtoon.comLinks to an external site.). If you would like to use a different media source, please email your Instructor first for permission.
POWTOON NOTE: This site features a mixture of paid and free items. YOU DO NOT HAVE TO PAY FOR PREMIUM ITEMS TO FULFILL THE REQUIREMENTS OF THE ASSIGNMENT. Great projects can be created just using their free tools (see the example below). Please watch the video below so that you avoid accidentally selecting elements that ask you to pay.
Instructions for How to Create a Completely FREE Project Using Powtoon:
Instructions on How to Use These Tools:
How to Use Canva:
How to Use Powtoon:
How to Submit Your Finished Canva Infographic:
How to Submit Your Finished PowToon:
Examples to get you started:
Infographic Example:
Alternate LinkLinks to an external site.

Categories
Pathophysiology

Title: Understanding Acid-Base Imbalance: A Case Study Analysis using the ROME Mnemonic

Discussion Assignment: Referencing the ROME mnemonic listed below, submit a discussion post supported by at least one reference explaining the significance of the following lab results. Submit your results as your discussion contribution.
In this week’s reading material, you are learning about the importance of acid-base balance in maintaining homeostasis. The acid-base balance must be maintained within a narrow range in order for the body to function normally. Please read over the following case study to address the questions below. Please reference the ROME mnemonic listed below as needed. Don’t forget to cite your sources! 
Mrs. Breathless is a 45-year-old female nurse with a history of asthma. She reports to the ED in the early morning with shortness of breath, blurred vision, headache, and restlessness. After several laboratory tests, the following ABG (arterial blood gases) lab results are confirmed:  
Blood pH=7.30 
PaCO2 = 46 mm Hg 
HCO3 = 24 mEq/L.  
Based on the results of her ABG, which acid-base imbalance is Mrs. Breathless likely experiencing? Justify your answer by referencing the ROME mnemonic. 
What is the underlying pathophysiology of this disorder? What type of compensation is likely to take place? 
Why do you think Mrs. Breathless developed this imbalance? What are some of the contributing factors leading to this? 

Categories
Pathophysiology

Title: Diabetic Ketoacidosis: A Case Study

A 21-year old female (A.M.) presents to the urgent care clinic with symptoms of nausea, vomiting, diarrhea, and a fever for 3 days. She states that she has Type I diabetes and has not been managing her blood sugars since she’s been ill and unable to keep any food down. She’s only tolerated sips of water and juices. Since she’s also been unable to eat, she hasn’t taken any insulin as directed. While helping A.M. from the lobby to the examining room you note that she’s unsteady, her skin is warm and flushed, and that she’s drowsy. You also note that she’s breathing rapidly and smell a slight sweet/fruity odor. A.M. has a challenge answering questions but keeps asking for water to drink.
You get more information from A.M. and learn the following:
She had some readings on her glucometer which were reading ‘high’
She vomits almost every time she takes in fluid
She hasn’t voided for a day but voided a great deal the day before
She’s been sleeping long hours and finally woke up this morning and decided to seek care
Vital Sign
Temperature                      
101.3° F (tympanic)
Blood pressure
88/46 mmHg
Heart rate
132 beats/minute
Respiratory rate
36 breaths/min, deep
Oxygen saturation % (SpO2)
91% on room air
Lab results
Serum glucose
657 mg/dl
Serum potassium
6.2 mEq/L
Urine ketones
Positive
What is the disorder and its pathophysiology that you expect the health care provider to diagnose?
Describe the etiology of the disorder A.M is experiencing.
Identify and describe the clinical manifestations of the disorder A.M. is experiencing.
Instructions:
Summarize the questions above and formulate what may be happening with A.M.
Use at least one scholarly source to support your findings. Examples of scholarly sources include academic journals, textbooks, reference texts, and CINAHL nursing guides. Be sure to cite your sources in-text and on a References page using APA format.
You can find useful reference materials for this assignment in the School of Nursing guide: https://guides.rasmussen.edu/nursing/referenceebooks
Have questions about APA? Visit the online APA guide: https://guides.rasmussen.edu/apa
Case study adapted from:
Harding, M.M. & Snyder, J.S. (2015). Winningham’s critical thinking cases in nursing: Medical-surgical, pediatric, maternity, and psychiatric. Retrieved from: https://ebookcentral.proquest.com/lib/ras/detail.action?docID=2072336.

Categories
Pathophysiology

Acid-Base Imbalance in a Patient with Asthma: A Case Study and Analysis

Discussion Assignment: Referencing the ROME mnemonic listed below, submit a discussion post supported by at least one reference explaining the significance of the following lab results. Submit your results as your discussion contribution.
In this week’s reading material, you are learning about the importance of acid-base balance in maintaining homeostasis. The acid-base balance must be maintained within a narrow range in order for the body to function normally. Please read over the following case study to address the questions below. Please reference the ROME mnemonic listed below as needed. Don’t forget to cite your sources! 
Mrs. Breathless is a 45-year-old female nurse with a history of asthma. She reports to the ED in the early morning with shortness of breath, blurred vision, headache, and restlessness. After several laboratory tests, the following ABG (arterial blood gases) lab results are confirmed:  
Blood pH=7.30 
PaCO2 = 46 mm Hg 
HCO3 = 24 mEq/L.  
Based on the results of her ABG, which acid-base imbalance is Mrs. Breathless likely experiencing? Justify your answer by referencing the ROME mnemonic. 
What is the underlying pathophysiology of this disorder? What type of compensation is likely to take place? 
Why do you think Mrs. Breathless developed this imbalance? What are some of the contributing factors leading to this? 
RO-ME:
Respiratory Opposite: When pH is up, PaCO2 is down = Alkalosis, When pH is down, PaCO2 is up = Acidosis
Metabolic Equal: When pH is up, HCO3 is up = Alkalosis, When pH is down, HCO3 is down = Acidosis
https://www.news-medical.net/news/20240514/Experts-advocate-for-terminology-change-in-brain-injury-research.aspx

Categories
Pathophysiology

“Understanding Hypertension: Incidence, Pathophysiology, and Management for Advanced Practice Nurses” “Assessing the Use of Citations and Extended Referencing in Academic Writing: A Critical Analysis”

Cardiovascular/Pulmonary PowerPoint Presentation
Goal: Develop a PowerPoint presentation on hypertension discussed in the McCance text.
The presentation must provide information about the incidence, prevalence, and pathophysiology of the disease/disorder to the cellular level. The presentation must educate advanced practice nurses on assessment and care/treatment, including genetics/genomics—specific for this disorder. Patient education for management, cultural, and spiritual considerations for care must also be addressed. The presentation must specifically address how the disease/disorder affects 1 of the following age groups: infant/child, adult, or elderly.
Format Requirements: 
Presentation is original work and logically organized.
Followed APA format including citation of references.
Power point presentation with 10-15 slides were clear and easy to read. Speaker notes expanded upon and clarified content on the slides.
Incorporate a minimum of 4 current (published within last five years) scholarly journal articles or primary legal sources (statutes, court opinions) within your work. Journal articles and books should be referenced according to APA style (the library has a copy of the APA Manual).
Content Requirements: 
Select a cardiovascular or pulmonary disorder.
Provide information about the incidence, prevalence, and pathophysiology of the disease/disorder to the cellular level.
Educate advanced practice nurses on assessment and care/treatment, including genetics/genomics—specific for this disorder.
Provide patient education for management, cultural, and spiritual considerations for care must also be addressed.
Must specifically address how the disease/disorder affects 1 of the following age groups: infant/child, adult, or elderly.
Submission Requirements
Complete and submit the assignment on module 7 by 11:59 PM ET Friday
Attention: Complete and submit the assignment by 11:59 PM ET Friday.
Late work policies, expectations regarding proper citations, acceptable means of responding to peer feedback, and other expectations are at the discretion of the instructor.
You can expect feedback from the instructor within 48 to 72 hours from the Friday due date. 
Grading Rubric 
Your assignment will be graded according to the grading rubric.
Presentation Rubric
Presentation Rubric
Criteria Ratings Pts
Identification of Main Issues/Problems
4 pts
Distinguished
Identify and demonstrate a sophisticated understanding of the issues/problems.
3 pts
Excellent
Identifies and demonstrate an accomplished understanding of most of issues/problems.
2 pts
Fair
Identifies and demonstrate an an acceptable understanding of most of issues/problems.
1 pts
Poor
Identifies and demonstrate an unacceptable understanding of most of issues/problems.
/ 4 pts
Analysis and Evaluation of Issues/Probelms
4 pts
Distinguished
Presents an insightful, thorough analysis and evaluation of issues/problems.
3 pts
Excellent
Presents a thorough analysis and evaluation of most of the issues/problems.
2 pts
Fair
Presents a superficial or incomplete analysis and evaluation of issues/problems.
1 pts
Poor
Presents unacceptable analysis and evaluation of issues/problems.
/ 4 pts
Demonstrates a Conceptual Understanding
4 pts
Distinguished
Provides a thorough, competent and interpretive responses to all issues/problems, and shows a high level of conceptual understanding.
3 pts
Excellent
Provides a competent and interpretive responses to all issues/problems, and shows a moderate level of conceptual understanding.
2 pts
Fair
Provides a competent responses to all issues/problems, but lacks interpretation and a moderate level of conceptual understanding.
1 pts
Poor
Provides an unacceptable response to all issues/problems, and lacks interpretation and a moderate level of conceptual understanding.
/ 4 pts
Use of Citations to Course Readings and Additional Research/Literature
4 pts
Distinguished
Effectively uses the literature and other resources to inform their work. Exceptional use of citations and extended referencing.
3 pts
Excellent
Effectively uses the literature and other resources to inform their work. Moderate use of citations and extended referencing.
2 pts
Fair
Ineffectively uses the literature and other resources to inform their work. Moderate use of citations and extended referencing.
1 pts
Poor
Ineffectively uses the literature and other resources to inform their work. An unacceptable use of citations and extended referencing.
/ 4 pts
Writing Mechanics and APA Formatting Guidelines
view longer description
4 pts
Full Marks
Demonstrate a high level of clarity, precision, and attention to detail. APA style is correct and writing is free of grammar and spelling errors.
3 pts
Excellent
Demonstrate a high level of clarity. APA style and writing mechanics need more precision and attention to detail.
2 pts
Fair
Demonstrate a moderate level of clarity. APA style and writing mechanics need more precision and attention to detail.
1 pts
Poor
Demonstrates issues in writing and communicating clearly. APA style and writing mechanics need serious attention.
/ 4 pts
Total Points: 0

Categories
Pathophysiology

“Hematopoietic and Cardiovascular Case Studies: Assessing Risk Factors and Treatment Options” “Understanding Acute Coronary Events: A Case Study Analysis and Discussion”

Hematopoietic: 
J.D. is a 37 years old white woman who presents to her gynecologist complaining of a 2-month history of intermenstrual bleeding, menorrhagia, increased urinary frequency, mild incontinence, extreme fatigue, and weakness. Her menstrual period occurs every 28 days and lately there have been 6 days of heavy flow and cramping. She denies abdominal distension, back-ache, and constipation. She has not had her usual energy levels since before her last pregnancy. 
Past Medical History (PMH):
Upon reviewing her past medical history, the gynecologist notes that her patient is a G5P5with four pregnancies within four years, the last infant having been delivered vaginally four months ago. All five pregnancies were unremarkable and without delivery complications. All infants were born healthy. Patient history also reveals a 3-year history of osteoarthritis in the left knee, probably the result of sustaining significant trauma to her knee in an MVA when she was 9 years old. When asked what OTC medications she is currently taking for her pain and for how long she has been taking them, she reveals that she started taking ibuprofen, three tablets each day, about 2.5 years ago for her left knee. Due to a slowly progressive increase in pain and a loss of adequate relief with three tablets, she doubled the daily dose of ibuprofen. Upon the recommendation from her nurse practitioner and because long-term ibuprofen use can cause peptic ulcers, she began taking OTC omeprazole on a regular basis to prevent gastrointestinal bleeding. Patient history also reveals a 3-year history of HTN for which she is now being treated with a diuretic and a centrally acting antihypertensive drug. She has had no previous surgeries. 
Case Study Questions
Name the contributing factors on J.D that might put her at risk to develop iron deficiency anemia.
Within the case study, describe the reasons why J.D. might be presenting constipation and or dehydration.
Why Vitamin B12 and folic acid are important on the erythropoiesis? What abnormalities their deficiency might cause on the red blood cells?
The gynecologist is suspecting that J.D. might be experiencing iron deficiency anemia. 
In order to support the diagnosis, list and describe the clinical symptoms that J.D. might have positive for Iron deficiency anemia.
If the patient is diagnosed with iron deficiency anemia, what do you expect to find as signs of this type of anemia? List and describe.
Labs results came back for the patient. Hb 10.2 g/dL; Hct 30.8%; Ferritin 9 ng/dL; red blood cells are smaller and paler in color than normal. Research list and describe for appropriate recommendations and treatments for J.D.
Cardiovascular 
Mr. W.G. is a 53-year-old white man who began to experience chest discomfort while playing tennis with a friend. At first, he attributed his discomfort to the heat and having had a large breakfast. Gradually, however, discomfort intensified to a crushing sensation in the sternal area and the pain seemed to spread upward into his neck and lower jaw. The nature of the pain did not seem to change with deep breathing. When Mr. G. complained of feeling nauseated and began rubbing his chest, his tennis partner was concerned that his friend was having a heart attack and called 911 on his cell phone. The patient was transported to the ED of the nearest hospital and arrived within 30 minutes of the onset of chest pain. In route to the hospital, the patient was placed on nasal cannula and an IV D5W was started. Mr. G. received aspirin (325 mg po) and 2 mg/IV morphine. He is allergic to meperidine (rash). His pain has eased slightly in the last 15 minutes but is still significant; was 9/10 in severity; now7/10. In the ED, chest pain was not relieved by 3 SL NTG tablets. He denies chills. 
Case Study Questions
For patients at risk of developing coronary artery disease and patients diagnosed with acute myocardial infarct, describe the modifiable and non-modifiable risk factors.
What would you expect to see on Mr. W.G. EKG and which findings described on the case are compatible with the acute coronary event?
Having only the opportunity to choose one laboratory test to confirm the acute myocardial infarct, which would be the most specific laboratory test you would choose and why?
How do you explain that Mr. W.G temperature has increased after his Myocardial Infarct, when that can be observed and for how long? Base your answer on the pathophysiology of the event.
Explain to Mr. W.G. why he was experiencing pain during his Myocardial Infarct. Elaborate and support your answer.
Submission Instructions:
Include both case studies in your post.
Your initial post should be at least 500 words, formatted and cited in current APA style with support from at least 2 academic sources. Your initial post is worth 8 points.
You should respond to at least two of your peers by extending, refuting/correcting, or adding additional nuance to their posts. Your reply posts are worth 2 points (1 point per response.) 
All replies must be constructive and use literature where possible.
Please post your initial response by 11:59 PM ET Thursday, and comment on the posts of two classmates by 11:59 PM ET Sunday.
You can expect feedback from the instructor within 48 to 72 hours from the Sunday due date. 
Grading Rubric 
Your assignment will be graded according to the grading rubric.
Discussion Rubric
Criteria Ratings Points
Identification of Main Issues, Problems, and Concepts
Distinguished – 5 points 
Identifies and demonstrates a sophisticated understanding of the issues, problems, and concepts.
Excellent – 4 points 
Identifies and demonstrates an accomplished understanding of most issues, problems, and concepts.
Fair – 1-3 points
Identifies and demonstrates an acceptable understanding of most issues, problems, and concepts.
Poor – 0 points
Identifies and demonstrates an unacceptable understanding of most issues, problems, and concepts. Or nothing was posted.
5 points
Use of Citations, Writing Mechanics, and APA Formatting Guidelines
Distinguished – 3 points
Effectively uses the literature and other resources to inform their work. Exceptional use of citations and extended referencing. High level of APA precision and free of grammar and spelling errors.
Excellent – 2 points
Effectively uses the literature and other resources to inform their work. Moderate use of citations and extended referencing. Moderate level of APA precision and free of grammar and spelling errors.
Fair – 1 point
Ineffectively uses the literature and other resources to inform their work. Moderate use of citations and extended referencing. APA style and writing mechanics need more precision and attention to detail.
Poor – 0 points
Ineffectively uses the literature and other resources to inform their work. Unacceptable use of citations and extended referencing. APA style and writing mechanics need serious attention. Or nothing was posted.
3 points
Response to Posts of Peers
Distinguished – 2 points
Student constructively responded to two other posts and either extended, expanded, or provided a rebuttal to each.
Fair – 1 point
Student constructively responded to one other post and either extended, expanded, or provided a rebuttal.
Poor – 0 points
Student provided no response to a peer’s post.
2 points
Total Points  10

Categories
Pathophysiology

Diabetic Ketoacidosis: A Case Study A.M. is a 21-year-old female with a history of Type I diabetes who presents to the urgent care clinic with symptoms of nausea, vomiting, diarrhea, and a fever. Upon examination

Using the case study below, prepare a 2 – 3-page paper.
A 21-year old female (A.M.) presents to the urgent care clinic with symptoms of nausea, vomiting, diarrhea, and a fever for 3 days. She states that she has Type I diabetes and has not been managing her blood sugars since she’s been ill and unable to keep any food down. She’s only tolerated sips of water and juices. Since she’s also been unable to eat, she hasn’t taken any insulin as directed. While helping A.M. from the lobby to the examining room you note that she’s unsteady, her skin is warm and flushed, and that she’s drowsy. You also note that she’s breathing rapidly and smell a slight sweet/fruity odor. A.M. has a challenge answering questions but keeps asking for water to drink.
You get more information from A.M. and learn the following:
She had some readings on her glucometer which were reading ‘high’
She vomits almost every time she takes in fluid
She hasn’t voided for a day but voided a great deal the day before
She’s been sleeping long hours and finally woke up this morning and decided to seek care
Vital Sign
Temperature                      
101.3° F (tympanic)
Blood pressure
88/46 mmHg
Heart rate
132 beats/minute
Respiratory rate
36 breaths/min, deep
Oxygen saturation % (SpO2)
91% on room air
Lab results
Serum glucose
657 mg/dl
Serum potassium
6.2 mEq/L
Urine ketones
Positive
What is the disorder and its pathophysiology that you expect the health care provider to diagnose?
Describe the etiology of the disorder A.M is experiencing.
Identify and describe the clinical manifestations of the disorder A.M. is experiencing.
Instructions:
Summarize the questions above and formulate what may be happening with A.M.
Use at least one scholarly source to support your findings. Examples of scholarly sources include academic journals, textbooks, reference texts, and CINAHL nursing guides. Be sure to cite your sources in-text and on a References page using APA format.
Use of internet sites / sources will not be approved references for this and future assignments.
Have questions about APA? Visit the online APA guide: https://guides.rasmussen.edu/apa
Case study adapted from:
Harding, M.M. & Snyder, J.S. (2015). Winningham’s critical thinking cases in nursing: Medical-surgical, pediatric, maternity, and psychiatric. Retrieved from: https://ebookcentral.proquest.com/lib/ras/detail.action?docID=2072336.
Submit your completed assignment by following the directions linked below. Please check the Course Calendar for specific due dates.
Save your assignment as a Microsoft Word document. (Mac users, please remember to append the “.docx” extension to the filename.) The name of the file should be your first initial and last name, followed by an underscore and the name of the assignment, and an underscore and the date. An example is shown below:

Categories
Pathophysiology

Title: “The Journey of High Grade Ovarian Serous Carcinoma: A Case Study”

required to create a 7-minute vodcast (a videorecording with audio (only provide me with dialogue script), written text and pictures/diagrams) about a person who has a disease of your choice: High Grade Ovarian Serous arcinoma
Vodcast needs to be presented as a case study where you outline: 
Your person’s name and relevant demographic details 
A brief description of their medical history 
A brief description that led to the diagnosis of their disease (really important to find reasons for everything)
You will then be required to address the following and relate your answers to your person. 
Explain the aetiology of their disease. 
Explain the pathogenesis of their disease. 
Explain how the pathogenesis of their disease relates to their clinical manifestations. 
As well start with an introduction of what is ovarian serous carcinoma, their statistics, andtypes, plus other useful information before starting with case study.
You need to include an annotated reference list at the end of your vodcast presentation. An annotated reference list briefly describes how each source was used in the development of your vodcast presentation. 
Your annotated reference list work needs to be formatted in accordance with APA 7th edition referencing guidelines. 
Vodcast needs to be your own original work; you cannot include YouTube clips or other videos as part of this assessment task.
I have included a marking criteria, please refer to this!!! 
if you need more information please ask.
No A.I use, and need of proof of no use and plagarism

Categories
Pathophysiology

“Exploring the Pathophysiology of Chronic Kidney Disease: A Case Study”

Your signature assignment requires you to research a pathophysiologic topic of interest and create a case study to present information about your topic. You may choose to research and write about ANY pathophysiologic topic of interest to you (it can be a topic we have covered or a completely new one). I am not choosing the topics for you. Remember, you are not looking for an existing case study, instead you are creating the case study (you get to MAKE IT UP, so be creative). The paper must be written in APA format.

Categories
Pathophysiology

Title: Understanding the Pathophysiology, Etiology, and Clinical Manifestations of Chlamydia Infection

Select a sexually transmitted infection (STI) and do research on it. Write a 3-5 page paper about the condition/issue. In the paper discuss the concepts below:
What is the pathophysiology of one STI
What is the etiology of the selected STI
What are the clinical manifestations of the selected STI
label paragraphs use in text citation
Use of internet sites / sources will not be approved references